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Tirzepatide is a dual GIP/GLP-1 receptor agonist that produces mean body weight reductions of 20.9% at 72 weeks by delaying gastric emptying, suppressing ghrelin rebound, and enhancing glucose-dependent insulin secretion

Absorbed vitamin B12 is transported via specific B12 binding proteins, transcobalamin I and II to the various tissues

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

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